Lipid raft idea is floated

Lipid raft idea is floated

T he introduction of a fl uorescent lipid probe, specifi cally fl uorescent ceramide, in the mid-1980s (Lipsky and Pagano, 1983; Lipsky and Pagano, 1985) gave Gerrit van Meer and Kai Simons just the tool they needed to attack a nagging question. Lipid locations For a decade, it had been known that the apical and basolateral membranes of epithelial cells had different lipid compositions (Kawai, ...

Lipid Raft Microdomains

Spatiotemporal aspects of filovirus entry and release are poorly understood. Lipid rafts act as functional platforms for multiple cellular signaling and trafficking processes. Here, we report the compartmentalization of Ebola and Marburg viral proteins within lipid rafts during viral assembly and budding. Filoviruses released from infected cells incorporated raft-associated molecules, suggestin...

Stomatin is a major lipid-raft component of platelet granules

Lipid rafts are detergent-resistant, cholesteroland sphingolipid-rich membrane domains that are involved in important cellular processes such as signal transduction and intracellular trafficking. Stomatin, a major lipid-raft component of erythrocytes and epithelial cells, is also an abundant platelet protein. Microscopical methods and subcellular fractionation showed that stomatin is located ma...

Lipid Raft-Associated GTPase Signaling

Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition

Background Toll like receptors (TLRs) are an important and evolutionary conserved class of pattern recognition receptors associated with innate immunity. The recognition of Gram-positive cell wall constituents strongly depends on TLR2. In order to be functional, TLR2 predominantly forms a heterodimer with TLR1 or TLR6 within specialized membrane microdomains, the lipid rafts. The membrane lipid...